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IDMC has concluded that OlympiA trial of Lynparza crossed superiority boundary for invasive disease-free survival vs. placebo at planned interim analysis

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OlympiA Phase III trial of Lynparza in the adjuvant treatment of BRCA-mutated high-risk HER2-negative early breast cancer will be analysed and reported early

The OlympiA Phase III trial for AstraZeneca and MSD’s Lynparza will move to early primary analysis and reporting following a recommendation from the Independent Data Monitoring Committee (IDMC).

Based on the planned interim analysis, the IDMC concluded that the trial crossed the superiority boundary for its primary endpoint of invasive disease-free survival (iDFS) and demonstrated a sustainable, clinically relevant treatment effect for Lynparza versus placebo for patients with germline BRCA-mutated (gBRCAm) high-risk human epidermal growth factor receptor 2 (HER2)-negative early breast cancer, and recommend primary analysis now take place. 

The OlympiA Phase III trial is a partnership between Breast International Group (BIG), NRG Oncology, the US National Cancer Institute (NCI), Frontier Science & Technology Research Foundation (FSTRF), AstraZeneca and MSD.1 The trial is sponsored by NRG Oncology in the US and by AstraZeneca outside the US.

An estimated 2.3 million women were diagnosed with breast cancer worldwide in 2020, and BRCA mutations are found in approximately 5% of breast cancer patients.2-10 Around 55-65% of women with a BRCA1 mutation and approximately 45% with a BRCA2 mutation will develop breast cancer before the age of 70.11

 Andrew Tutt, Global Chair of the OlympiA Phase III trial and Professor, Institute of Cancer Research and Kings College London, said: “We are delighted that our global academic and industry partnership has been able to help investigate a possible personalised treatment for women with hereditary breast cancer. The most common cause of hereditary breast cancer is an inherited mutation in the BRCA1 or BRCA2 genes which also may cause the disease to develop at a significantly earlier age than is usual. The OlympiA trial has allowed us to go beyond using genetic testing to identify patients who are at risk of this disease and explore the potential of Lynparza to prevent disease recurrence for these patients. We look forward to analysing and presenting the full results of the trial at a forthcoming medical meeting.”

José Baselga, Executive Vice President, Oncology R&D, said: “Breast cancer remains one of the most common cancers globally and despite advances in treatment, many patients with high-risk disease will unfortunately develop a recurrence. We look forward to reviewing the results.”

Roy Baynes, Senior Vice President and Head of Global Clinical Development, Chief Medical Officer, MSD Research Laboratories, said: “ Analysis of the OlympiA trial, based upon the IDMC recommendation, could represent a potential step forward for patients with early-stage, high-risk primary breast cancer with a germline BRCA mutation.”

In its communication, the IDMC did not raise any new safety concerns. The trial will continue to assess the key secondary endpoints of overall survival and distant disease-free survival.

Early breast cancer

Breast cancer is the most common cancer among women worldwide and an estimated 90% of all breast cancer is diagnosed at an early stage.12,13 Breast cancer is one of the most biologically diverse tumour types with various factors fuelling its development and progression.14 The discovery of biomarkers in the development of breast cancer has greatly impacted scientific understanding of the disease.15

BRCA1 and BRCA2

BRCA1 and BRCA2 (breast cancer susceptibility genes 1/2) are human genes that produce proteins responsible for repairing damaged DNA and play an important role maintaining the genetic stability of cells. When either of these genes is mutated or altered such that its protein product either is not made or does not function correctly, DNA damage may not be repaired properly, and cells become unstable. As a result, cells are more likely to develop additional genetic alterations that can lead to cancer and confer sensitivity to PARP inhibitors including Lynparza.16-19

OlympiA

OlympiA is a Phase III, double-blind, parallel group, placebo-controlled, multicentre trial testing the efficacy and safety of Lynparza tablets versus placebo as adjuvant treatment in patients with gBRCAm high-risk HER2-negative early breast cancer, who have completed definitive local treatment and neoadjuvant or adjuvant chemotherapy. The primary endpoint of the trial is iDFS defined as time from randomisation to date of first treatment failure that is loco-regional or distant recurrence or new cancer or death from any cause.1

NRG Oncology

NRG Oncology is a network group funded by the NCI, a part of the National Institutes of Health. All of the NCI funded network groups participated in the trial. The NCI and AstraZeneca are collaborating under a Cooperative Research and Development Agreement.

NRG Oncology brings together the National Surgical Adjuvant Breast and Bowel Project, the Radiation Therapy Oncology Group, and the Gynaecologic Oncology Group, with the mission to improve the lives of cancer patients by conducting practice-changing multi-institutional clinical and translational research.

BIG

The Breast International Group (BIG) is an international not-for-profit organisation for academic breast cancer research groups from around the world, based in Brussels, Belgium.

Founded by leading European opinions leaders in 1999, the organisation aims to address fragmentation in European breast cancer research and now represents a network of over 55 like-minded research groups affiliated with specialised hospitals, research centres and leading experts across approximately 70 countries on six continents.

 BIG’s research is supported in part by its philanthropy unit, known as BIG against breast cancer, which is used to interact with the general public and donors, and to raise funds for BIG’s purely academic breast cancer trials and research programmes.

FSTRF

Frontier Science & Technology Research Foundation (FSTRF) is a non-profit, research organisation which supports research networks, pharmaceutical companies and investigators to conduct scientifically meaningful high-quality clinical trials. The OlympiA trial involved research staff in the US and in the Affiliate office in Scotland.

FSTRF works with scientists and technicians in more than 800 laboratories, universities and medical centres around the world to provide a comprehensive range of research services throughout the clinical trial process including design, analysis and reporting.

Through its work, FSTRF aims to advance the application of statistical science and practice and data management techniques in science, healthcare and education.

Lynparza

Lynparza (olaparib) is a first-in-class PARP inhibitor and the first targeted treatment to block DNA damage response (DDR) in cells/tumours harbouring a deficiency in homologous recombination repair (HRR), such as mutations in BRCA1 and/or BRCA2. Inhibition of PARP with Lynparza leads to the trapping of PARP bound to DNA single-strand breaks, stalling of replication forks, their collapse and the generation of DNA double-strand breaks and cancer cell death. Lynparza is being tested in a range of PARP-dependent tumour types with defects and dependencies in the DDR pathway.

Lynparza is currently approved in a number of countries, including those in the EU, for the maintenance treatment of platinum-sensitive relapsed ovarian cancer. It is approved in the US, the EU, Japan, China, and several other countries as 1st-line maintenance treatment of BRCA-mutated advanced ovarian cancer following response to platinum-based chemotherapy. It is also approved in the US, EU and Japan as a 1st-line maintenance treatment with bevacizumab for patients with homologous recombination deficient (HRD)-positive advanced ovarian cancer (BRCAm and/or genomic instability). Lynparza is approved in the US, Japan, and a number of other countries for germline BRCA-mutated, HER2-negative, metastatic breast cancer, previously treated with chemotherapy; in the EU, this includes locally advanced breast cancer. It is also approved in the US, the EU, Japan and several other countries for the treatment of gBRCAm metastatic pancreatic cancer. Lynparza is approved in the US for HRR gene-mutated metastatic castration-resistant prostate cancer (BRCAm and other HRR gene mutations) and in the EU and Japan for BRCAm metastatic castration-resistant prostate cancer. Regulatory reviews are underway in several countries for ovarian, breast, pancreatic and prostate cancers.

Lynparza, which is being jointly developed and commercialised by AstraZeneca and MSD, has been used to treat over 40,000 patients worldwide. Lynparza has the broadest and most advanced clinical trial development programme of any PARP inhibitor, and AstraZeneca and MSD are working together to understand how it may affect multiple PARP-dependent tumours as a monotherapy and in combination across multiple cancer types. Lynparza is the foundation of AstraZeneca’s industry-leading portfolio of potential new medicines targeting DDR mechanisms in cancer cells.

The AstraZeneca and MSD strategic oncology collaboration

In July 2017, AstraZeneca and Merck & Co., Inc., Kenilworth, NJ, US, known as MSD outside the US and Canada, announced a global strategic oncology collaboration to co-develop and co-commercialise Lynparza, the world’s first PARP inhibitor, and Koselugo (selumetinib), a mitogen-activated protein kinase (MEK) inhibitor, for multiple cancer types. Working together, the companies will develop Lynparza and Koselugo in combination with other potential new medicines and as monotherapies. Independently, the companies will develop Lynparza and Koselugo in combination with their respective PD-L1 and PD-1 medicines.

AstraZeneca in breast cancer

Driven by a growing understanding of breast cancer biology, AstraZeneca is starting to challenge, and redefine, the current clinical paradigm for how breast cancer is classified and treated to deliver even more effective treatments to patients in need – with the bold ambition to one day eliminate breast cancer as a cause of death.

AstraZeneca has a comprehensive portfolio of approved and promising compounds in development that leverage different mechanisms of action to address the biologically diverse breast cancer tumour environment. AstraZeneca aims to continue to transform outcomes for HR-positive breast cancer with foundational medicines Faslodex (fulvestrant) and Zoladex (goserelin) and the next-generation selective estrogen receptor degrader (SERD) and potential new medicine camizestrant (AZD9833). PARP inhibitor, Lynparza is a targeted treatment option for metastatic breast cancer patients with an inherited BRCA mutation. AstraZeneca with MSD continue to research Lynparza in metastatic breast cancer patients with an inherited BRCA mutation and are exploring new opportunities to treat these patients earlier in their disease state.

Building on the first approval of Enhertu (trastuzumab deruxtecan), a HER2-directed antibody-drug conjugate (ADC), in previously treated HER2-positive metastatic breast cancer, AstraZeneca and Daiichi Sankyo are exploring its potential in earlier lines of treatment and in new breast cancer settings. To bring much needed treatment options to patients with triple-negative breast cancer, an aggressive form of breast cancer, AstraZeneca is testing immunotherapy Imfinzi (durvalumab) in combination with other oncology medicines, including Lynparza and Enhertu, assessing the potential of AKT kinase inhibitor, capivasertib, in combination with chemotherapy, and collaborating with Daiichi Sankyo to explore the potential of TROP2-directed ADC, datopotamab deruxtecan.

AstraZeneca in oncology

AstraZeneca has a deep-rooted heritage in oncology and offers a quickly growing portfolio of new medicines that has the potential to transform patients’ lives and the Company’s future. With seven new medicines launched between 2014 and 2020, and a broad pipeline of small molecules and biologics in development, the Company is committed to advance oncology as a key growth driver for AstraZeneca focused on lung, ovarian, breast and blood cancers.

By harnessing the power of six scientific platforms – Immuno-Oncology, Tumour Drivers and Resistance, DNA Damage Response, Antibody Drug Conjugates, Epigenetics, and Cell Therapies – and by championing the development of personalised combinations, AstraZeneca has the vision to redefine cancer treatment and, one day, eliminate cancer as a cause of death.

AstraZeneca
AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of diseases in three therapy areas – Oncology, Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on Twitter @AstraZeneca.

Contacts

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References

1. ClinicalTrials.gov. Olaparib as Adjuvant Treatment in Patients with Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer (OlympiA). Available at https://clinicaltrials.gov/ct2/show/NCT02032823. Accessed February 2021.

2. GLOBOCAN. Breast Cancer. Available at https://gco.iarc.fr/today/data/factsheets/cancers/20-Breast-fact-sheet.pdf. Accessed February 2021.

3. Gomes M.C, et al. Prevalence of BRCA1 and BRCA2 Mutations in Breast Cancer Patients from Brazil. Breast Cancer Res Treat. 2007 Jul;103(3):349-53.

4. Hernandez J.E, et al. Prevalence of BRCA1 and BRCA2 Mutations in Unselected Breast Cancer Patients from Medellín, Colombia. Hered Cancer in Clin Pract. 2014;12:11.

5. Bu R, et al. Identification of Novel BRCA Founder Mutations in Middle Eastern Breast Cancer Patients Using Capture and Sanger Sequencing Analysis. Int J Cancer. 2016;139:1091-1097.

6. Abugattas J, et al. Prevalence of BRCA1 and BRCA2 Mutations in Unselected Breast Cancer Patients From Peru. Clin Genet. 2015 October;88(4):371-375.

7. Kast K, et al. Prevalence of BRCA1/2 Germline Mutations in 21,401 Families with Breast and Ovarian Cancer. J Med Genet. 2016;53:465-471.

8. Winter C, et al. Targeted Sequencing of BRCA1 and BRCA2 Across a Large Unselected Breast Cancer Cohort Suggests That One-third of Mutations Are Somatic. Ann Oncol. 2016;27:1532-1538.

9. Hoberg-Vetti H, et al. BRCA1/2 Testing in Newly Diagnosed Breast and Ovarian Cancer Patients Without Prior Genetic Counselling: the DNA-BONus Study. Eur J HumGenetic. 2016;24:881-888.

10. Kim R, et al. Incidence of germline BRCA1- and BRCA2-mutated Breast Cancer in the US. SABCS. 2017;poster P5-08-28.

11. National Breast Cancer Foundation. BRCA: The Breast Cancer Gene. Available at https://www.nationalbreastcancer.org/what-is-brca. Accessed February 2021.

12. SEER. SEER Cancer Statistics Review, 1975-2013. Available at http://seer.cancer.gov/csr/1975_2013/. Accessed February 2021.

13. Bertozzi S, et al. Biomarkers in Breast Cancer. Intechopen. 2018.

14. Yersal O, and Barutca S. Biological Subtypes of Breast Cancer: Prognostic and therapeutic implications. World J Clin Oncol. 2014;5(3):412-424.

15. Rivenbark A, et al. Molecular and Cellular Heterogeneity in Breast Cancer: Challenges for Personalized Medicine. Am J Pathol. 2013;183(4):1113-1124.

16. Roy R, et al. BRCA1 and BRCA2: Different Roles in a Common Pathway of Genome Protection. Nat Rev Cancer. 12(1):68-78.

17. Wu J, et al. The Role of BRCA1 in DNA Damage Response. Protein Cell. 2010;1(2):117-123.

18. Gorodetska I, et al. BRCA Genes: The Role in Genome Stability, Cancer Stemness and Therapy Resistance. J Cancer. 2019;10(9):2109-2127.

19. Li H, et al. PARP Inhibitor Resistance: The Underlying Mechanisms and Clinical Implications. Mol Cancer. 2020;19:107.

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AEGIRBIO AVGER BOKSLUTSKOMMUNIKÉ OCH REDOGÖR FÖR VÄSENTLIGA HÄNDELSER

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SAMMANFATTNING AV BOKSLUTSKOMMUNIKÉN

Med bolaget eller AegirBio AB avses AegirBio AB med organisationsnummer 559222-2953

Fjärde kvartalet i koncernen jämfört med samma period 2022

• Nettoomsättningen uppgick till 0 (0) MSEK

• Totala intäkter uppgick till 2,9 (0) MSEK

• Resultatet före skatt uppgick till -10,9 (-318,3) MSEK. 

• Kassabehållningen var vid slutet av kvartalet 12,1 (14,6) MSEK efter erhållen likvid om totalt 46,3 MSEK i första kvartalet till följd av utnyttjande av teckningsoptioner och konvertibellånet från Atlas.

Årets resultat i koncernen 2023 (2023-01-01 – 2023-12-31)

• Nettoomsättningen uppgick till 0 (1,7) MSEK

• Totala intäkter uppgick till 4,6 (5,2) MSEK

• Resultatet före skatt uppgick till -61,2 (-364,3) MSEK

• Resultat per aktie uppgick till -2,38 (-18,9)

• Soliditeten uppgick till -3% (60%)

Väsentliga händelser under och efter periodens utgång

2023

• AegirBio fortsätter att stärka upp sin organisation genom Dr. Vasiliki Fragkou som COO från 1 november 2023. Dr. Fragkou´s ledarskap som COO kommer att stärka företagets position som branschledare och driva innovation som i slutändan gynnar både patienter och vårdgivare. Dr. Fragkou kommer att ersätta Dr. Nils Paulsson.

• AegirBio fokuserar på RADx projektet och beslutar därför att inte längre upprätthålla CE-märkningen för MagniaReader therapeutic drug monitoring (TDM) testning. 

• AegirBio utser Christel Dahlberg till CFO med tillträde den 1 februari 2024. Christel Dahlberg har agerat som interim CFO för AegirBio sedan april 2023.

• Atlas Special Opportunities, LLC, påkallar partiell konvertering av utestående konvertibler till ett nominellt belopp om 5 MSEK.

 2024

• Den välrenommerade gastroenterologen Dr. Adam S. Cheifetz blir en del av AegirBios Scientific Advisory Board. Dr. Cheifetz är chef vid Center for Inflammatory Bowel Disease vid Beth Israel Deaconess Medical Center samt professor i medicin vid Harvard Medical School, tillför oöverträffad expertis inom området gastroeterologi, särskilt vid behandling av Crohns sjukdom, ulcerös kolit och andra inflammatoriska tarmsjukdomar. 

• AegirBios utökar sitt Scientific Advisory Board med professor Iain L.C Chapple, framstående tandläkare. Professor Chapple tillför erfarenhet och expertis till bolagets vetenskapliga råd och kommer att vara en av nycklarna till AegirBios strategi att mäta specifika biomarkörer i saliv med bolagets digitala plattform, för att förbättra den allmänna hälsan. 

• Finansinspektionen begär yttrande från AegirBio.

Marco Witteveen – CEO

Presenting the Q4 report, a reflection of our progress 

As we approach the conclusion of a fruitful year, I am delighted to share with you the Q4 report, summarizing our recent endeavors and celebrating the accomplishments that position us for continued success. This report will not only highlight our organizational achievements and cost management but will also spotlight significant scientific leadership appointments. 

Organizational Settling and Focused Pursuit

In a period characterized by relative tranquility, our focus on organizational consolidation and undivided attention to the RADx project have been unwavering. The establishment of a stable platform and strong leadership positions us favorably as we navigate the challenges and opportunities ahead.

RADx Project 

The RADx project continues to play a pivotal role in our strategic roadmap, and we are diligently progressing towards milestones 1 and 2 as scheduled. This success stands as a testament to the unwavering dedication and collaborative synergy of our teams in both the US and UK. Not only does this achievement reinforce our commitment to transparency, but it also underscores the project’s promising trajectory.

Scientific Leadership Appointments and Vision for a Scientific Advisory Board

As part of our ongoing commitment to scientific excellence, we have been aiming to establish a Scientific Advisory Board, recognizing the invaluable benefits such a board could bring to our strategic initiatives. This vision aligns with our dedication to advancing cutting-edge solutions and ensuring the highest standards of scientific rigor within our organization.

I am delighted to announce that in Q1-24, we had the excellent opportunity to welcome two esteemed professionals to our team. Dr. Adam S. Cheifetz, a renowned Gastroenterologist, now leads our Therapeutic Drug Monitoring solution, bringing invaluable expertise to this critical area. 

Furthermore, Professor Iain L. C. Chapple has joined our Scientific Advisory Board, bringing a wealth of experience as a distinguished dental professional. His insights will be pivotal in advancing our strategy to measure specific biomarkers in saliva through our digital platform, contributing to our overarching goal of improving overall health.

Financial Prudence and Cost Management 

Our commitment to financial prudence has yielded commendable results. Despite increased RADx project costs, we have successfully reduced overall expenses by 7.2 MSEK compared to 2022, a decrease with 11%. This achievement reflects our disciplined approach to contract negotiations and a strategic focus on essential expenditures.

Year-End Reflection and Future Endeavors

Looking back over the year, the success of our reorganization is evident. The strengthened synergy between entities and enhanced team spirit positions us well for the future. While celebrating our achievements, we remain mindful of the work ahead and are dedicated to building upon our successes.

Investor-Centric Perspective

This report is crafted with our investors in mind, highlighting the strengths that define our company. The addition of esteemed leaders, coupled with the achievement of RADx milestones, underscores our commitment to excellence. We stand poised for continued growth, and our achievements throughout the year are a testament to the dedication of the entire AegirBio team.

As we close this chapter, I extend my sincere gratitude to each member of the team for their unwavering commitment. Together, we have navigated challenges, celebrated successes, and positioned AegirBio for a future of continued growth and innovation.

Denna information är sådan som AegirBio är skyldigt att offentliggöra enligt EU:s marknadsmissbruksförordning (EU nr 596/2014). Informationen lämnades, genom angiven kontaktpersons försorg, för offentliggörande 2024-03-29 08:48 CET.

För ytterligare information, vänligen kontakta:
Marco Witteveen, CEO Aegirbio AB

Epost: ir@aegirbio.com
 

AegirBio i korthet

AegirBio är ett svenskt diagnostikföretag som grundades 2019 för att erbjuda tester för att övervaka och optimera doseringen av biologiska läkemedel via sin unika patenterade teknologiplattform. I juni 2020 noterades AegirBio på Nasdaq First North Growth Market. Bolagets ambition är, förutom att föra ut innovativ diagnostisk teknologi till marknaden, att göra diagnostik mer tillgänglig, enklare att använda och att ge korrekta och lätt överförbara resultat. För mer information, se Aegirbios hemsida www.aegirbio.com

Bolagets Certified Adviser är Eminova Fondkommission AB, adviser@eminova.se

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Clean Industry Solutions Holding Europe AB: Kvartalsrapport oktober-december 2023

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Q4 från 01-10-2023 till 31-12-2023 (01-10-2022 till 31-12-2022), FY från 01-01-2023 to 31-12-2023 (01-01-2022 to 31-12-2022)

Rapporten finns här: https://cleanindustrysolutions.com/sv/investerare/finansiella-rapporter/

Perioden i korthet – finansiell översikt för fjärde kvartalet

  • Intäkter uppgick till 7,8 MSEK
  • Övriga rörelseintäkter uppgick till 4,0 Mkr
  • Resultat från andelar i koncernföretag uppgick till 18,4 Mkr från den insolvensrelaterade dekonsolideringen av Industrial Solar GmbH
  • Rörelsekostnaderna för fjärde kvartalet uppgick till -7,2 Mkr
  • Rörelseresultatet (EBIT) för fjärde kvartalet uppgick till 19,0 Mkr
  • Det finansiella resultatet uppgick till -19,2 MSEK, främst på grund av dekonsolideringen av Industrial Solar GmbH
  • Resultat per aktie, före och efter utspädning, för det fjärde kvartalet uppgick till -0,0033 SEK
  • Kassaflödet från den löpande verksamheten för det fjärde kvartalet uppgick till -4,7 miljoner kronor
  • Eget kapital uppgick per 31-12 till 6,1 MSEK
  • Likvida medel uppgick per 31-12 till 7,0 Mkr

Viktiga händelser under rapporteringsperioden

  • Framgångsrik partnerutbildningsworkshop hos Industrial Solar
  • Clean Industry Solutions dotterbolag SolarSpring tecknar MOU med Aqualia
  • SolarSpring erhåller nationellt bidrag för FoU-projektet BEFuel
  • Clean Industry Solutions Holding Europe AB:s dotterbolag Industrial Solar GmbH kommer att ansöka om insolvensförfarande i Tyskland
  • Aalborgs universitet, Danmark, köper MD-pilotsystem för produktion av vatten med hög renhet

Viktiga händelser efter rapporteringsperioden

  • Clean Industry Solutions meddelar uppsägning av likviditetsgarantavtalet
  • Clean Industry Solutions Holding Europe AB:s dotterbolag Industrial Solar GmbH kommer att upphöra med sin verksamhet i slutet av februari
  • SolarSpring erhåller bidrag från EU LIFE-programmet för FoU-projektet SALTEAU
  • Clean Industry Solutions meddelar att Industrial Solars ledning har entledigats av insolvensförvaltaren

Kommentarer från VD Christian Zahler

Tyvärr var det fjärde kvartalet 2023 inte en fortsättning på de framgångar som vi kunde dela med oss av under årets tre första kvartal. Det är med stor sorg jag måste bekräfta att Industrial Solar tvingades upphöra med verksamheten i slutet av februari på grund av insolvens.
Detta är utan tvekan ett ögonblick av djup sorg för alla oss som har lagt ner vårt engagemang, vår passion och vårt hårda arbete för att göra företaget framgångsrikt. Till våra kollegor på Industrial Solar vill jag uttrycka min djupaste tacksamhet för deras orubbliga engagemang, kreativitet och hårda arbete. Var och en av dem har spelat en viktig roll i företagets resa, och deras engagemang har varit inget annat än inspirerande. Det är sorgligt men sant att omständigheter utanför vår kontroll har lett oss till denna punkt. Men låt oss inte glömma de otroliga prestationer som Industrial Solar har bidragit med till solvärmebranschen.    
Vi måste nu navigera genom okända vatten och göra det med en kollektiv anda av stöd och förståelse.  

 
Desto gladare är vi att SolarSpring för närvarande upplever ett ökande intresse för pilotsystem för membrandestillation från en mängd olika industrier och forskningscentra. Förutom produktion av högrent vatten för vätgaselektrolysatorer är de vanligaste tillämpningarna avlägsnande av ammoniak från avloppsvatten för vidare användning och volymreduktion av mycket salta avloppsvatten. Som meddelades i slutet av december har Aalborg Universitet (AAU) i Danmark köpt ett membrandestillationspilotsystem från SolarSpring GmbH med en nominell kapacitet på 100 liter högrent vatten per timme för att användas i samband med produktion av grön vätgas samt andra applikationer.

Finansiellt fortsatte koncernens uppåtgående trend under Q4 2023: På årsbasis är tillväxten i totala rörelseintäkter jämfört med förra året +47,5% (utan intäkter från aktier i koncernföretag, +87,9% inklusive dessa).    
På grund av Industrial Solar GmbH:s insolvens konsolideras inte längre dess balansräkning och dess resultaträkning konsolideras endast fram till insolvensens början. Även om vinsten från motsvarande konsolideringsposter måste elimineras genom att de läggs till som ”Resultat från andelar i koncernföretag” (18,4 MSEK), uppgår rörelseintäkterna fortfarande till 28,0 MSEK och når därmed en ny toppnotering.

Denna information är sådan som Clean Industry Solutions Holding Europe är skyldigt att offentliggöra enligt EU:s marknadsmissbruksförordning (EU nr 596/2014). Informationen lämnades, genom angiven kontaktpersons försorg, för offentliggörande 2024-03-29 08:45 CET.

Kontaktinformation:

Clean Industry Solutions Holding Europe AB
c/o Win-Win Ekonomi AB
Palmfeltsvägen 21
SE-121 62 Johanneshov/Sweden
E-Mail: info@cleanindustrysolutions.com

Amudova AB är Clean Industry Solutions’ certified adviser. Tel: 08-546 017 58
E-mail: info@amudova.se

Clean Industry Solutions Holding Europe AB äger 100% av SolarSpring GmbH, med säte i Freiburg/Tyskland.
SolarSpring GmbH, har utvecklats till en internationell pionjär inom membrandestillation som erbjuder innovativa lösningar och teknik för rening av avlopps- och dricksvatten.
Läs mer om SolarSpring GmbH på följande adress:
https://solarspring.de/en/

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Studie visar att styrketräning kan lindra depression

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En nyligen publicerad forskningsstudie i Psychiatry Research pekar på styrketräning

som en potentiell kompletterande behandlingsstrategi för att bekämpa depression.

Genom en metaanalys av 38 tidigare studier fann forskarna att styrketräning kan

minska depressiva symtom på ett måttligt sätt. Resultaten visar att längden på

träningen, hur ofta den utförs och specifika detaljer som antal set och repetitioner

påverkar effekten av träningen på depressionen.

Depression är en vanlig sjukdom som påverkar miljontals människor över hela

världen och trots tillgängliga behandlingar återhämtar sig många inte helt. Denna

studie ger därför viktig insikt i hur styrketräning kan vara en del av en effektiv

behandlingsstrategi för depression.

Källa: https://www.psypost.org/streng…

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