Simris Alg interim report January-September 2022






My objective for Q3 was to lay down a robust foundation for future sales revenue, and to complete the successful integration of Cyano Biotech GmbH, into the Simris structure. On the revenue front, the team has made great progress towards the December launch of our new Food Supplement products, improving the biosecurity of our production, and valorising additional extracts for B2B sales. In acquiring Cyano Biotech we have become pioneers in the field of Antibody Drug Conjugate (ADC)* medicines, providing drug developers with an entirely unique proposition for a next generation of ADC payloads produced by cyanobacteria. We now have our own R&D laboratories and hold broad patents covering a novel technology platform that gives us an accelerated entrance into the lucrative BioPharma space. I have a very clear view of where I want Simris to be in the next 5 years and am immensely proud that we are considerably closer to those objectives than we were just a few months ago when I began my appointment.

Generating sustainable sales revenue has been the biggest challenge for Simris throughout its history. This is why my top priority since joining in May, has been to build strong sales platforms for the short, medium, and long-term.

Towards the end of Q2, we initiated multiple projects aimed at building these platforms and much progress has been made during Q3. These projects are: (1) launching an improved range of microalgae-based food supplements; (2) enhancing the biosecurity and cultivation conditions of production to reliably increase product quality and yields; (3) identify and extract additional high-value compounds from our biomass as ingredients in B2C products or for sale to B2B customers.

I expect that our hard work will begin to show results in Q4, when we launch our new range of food supplements. The other projects will increasingly deliver revenue and margin throughout the first half of 2023.

Since acquiring Cyano Biotech in August, we have also invested considerable time to develop our understanding of their science and to build relationships with their target customers i.e., drug development companies. Importantly, these conversations are showing great promise.


Data from Amazon US confirms that more than 4m packs of Omega-3 are sold monthly from their marketplace. The potential for an attractively branded and reasonably priced algal Omega-3 is thus significant. Having studied trends in the existing market, the Team decided that a completely fresh approach was needed to unlock this potential.

The new concept is aimed both at converting those currently consuming Omega-3 from fish, to taking Omega-3 from algae, as well as winning over existing consumers of algal Omega-3.

Product: The capsules will contain twice as much EPA and DHA, and yet will be half the size of our historical product. This makes them much easier to swallow, an important factor for about 50% of US consumers and more than 60% of German consumers.**

Packaging: Capsules will be sold in a refill pouch, which is used to refill a Simris-branded storage jar. The storage jar is provided in a Starter Pack, along with two refill pouches. This approach minimises packaging inputs, facilitates low-cost shipping, reduces risk of breakage and is more environmentally responsible.

Price: By using less packaging we reduce direct packaging costs as well as indirect costs such as shipping and damages. This enables us to set a more accessible price, still with healthy margins, to drive volume sales.

Distribution: For the first time, Simris Omega-3 products can be sold into all major markets. In December we will begin selling directly to US consumers from Amazon US, and to Swedish consumers from our own web shop. The plan is to roll-out the range to new markets, with a focus on e-commerce and pharmacies in 2023.


Following with my appointment as CEO, I initiated a comprehensive risk review of Simris operations. As a result, it became clear that the single biggest production risk was biosecurity. During Q3 we engaged external consultants to conduct an independent audit of the company’s approach to biosecurity. Progress has already been made in updating our standard operating procedures (SOP’s), and in making the necessary investments in our production facility. These improvements reduce the risk of contamination as well as providing additional alerts when parameters such as temperature, pH, salinity etc are moving outside of the optimal range.

As expected, following an audit by LRQA at the end of October, Simris has once again been certified for the production and sale of food supplements under the criteria defined by Svensk Egenvård.  

Over this winter we will conduct trials aimed at establishing the optimal conditions for (1) biomass growth and (2) production of Fucoxanthin. To be able to conduct these trials we have moved one of our smaller photobioreactors into a closed room where we can control growth conditions (light &, heat) more closely. Results from these trials will help us to increase yields in 2023 and give us vital insights into the future of our production under the GMP certification required for the production of pharmaceutical products.


Historically, Simris has either extracted only EPA from its biomass or sold biomass to customers for them to process and extract molecules of interest.

At the start of Q3 we changed our mindset and set ourselves the challenge to be able to extract and sell multiple high value molecules/ products from the same biomass. Over the past three months we have developed a process to produce an oleoresin extract rich in Fucoxanthin after already having extracted EPA oil using CO2.

Studies have demonstrated Fucoxanthin to offer potential health benefits for the prevention of chronic diseases, including cancer, obesity, diabetes mellitus, and liver disease. Fucoxanthin is therefore a high value molecule, already well known to us as it was the target molecule within the biomass Simris sold B2B during 2021 and in Q1 of this year.

This opens up the potential to create new consumer products containing Fucoxanthin and to sell a Fucoxanthin rich oil/ oleoresin to B2B customers. Further work is planned through Q4 and into Q1 of next year to (1) define additional Fucoxanthin products; (2) confirm their stability/ shelf-life and (3) establish further molecules of interest/ products that can be produced from the same biomass, for example novel ingredients for cosmetics.


Following our acquisition of Cyano Biotech, I attended the world’s biggest Antibody Drug Conjugate* (ADC) conference at the start of September. Having talked with dozens of experts in the ADC field during and after this event, I am even more convinced that Simris will generate significant revenue from our ADC technology in the coming years.

Drug developers are looking for novel payloads that can be used to develop the next generation of cancer drugs. Whilst still in the pre-clinical phase, Simris now holds a library of cyanobacterial toxins which will provide a pipeline of novel ADC payloads. We also hold a broad patent covering the method by which our payloads are produced. The methodology offers significant potential for the modification of payloads to be both highly potent and highly specific in killing only cancer cells at extremely low concentrations. Achieving this will drastically improve the quality of life of cancer patients undergoing treatment.

Agreements between drug developers and companies offering payloads include up-front payments to license the technology towards a specific target, milestone payments and royalties. For payloads gaining regulatory approval, such agreements can be worth hundreds of millions of dollars.

With our newly acquired library of cyanobacterial strains and payload classes, and as the only company growing ready to conjugate ADC payloads, Simris is unique within the ADC field. Whilst it is still early days, I am encouraged by the interest we have already been able to generate and from the discussions we are currently engaged in with drug developers. 

Through the acquisition of Cyano Biotech, Simris now has its own Research & Development (R&D) laboratories with an in-house R&D team, based in Berlin. As a result, we have cancelled our cooperation with the University of Anhalt, and this is estimated to save Sirmis around €100k a year.

The founders of Cyano Biotech are now our CSO’s. Dr Dan Enke is CSO for ADC Technology, and Dr Heike Enke is CSO for all non-ADC Technology.


Simris has made big steps towards profitability this year. Year to date Sales Revenues are up 19% and on a like for like basis, excluding one-time costs in 2021, EBIT is up 3.3MSEK. This has been achieved through tight cost control whilst building the future sales platforms.

I would like to take this opportunity to thank you for your continued support of Simirs as we take the steps that will lead us towards a profitable future.

The report is published on Simris Algs website:

For more information contact:
Julian Read
CEO Simris Alg AB
Email: julian.read@simris.com
Mobile: +46767888212

This information is information that Simris Alg AB is obliged to make public according to the EU’s market abuse regulation. This information was provided by the above contact person for publication on 2022-11-09 at 08:00 AM CEST.

Simris Alg is a biologics company identifying high value, natural, biologically active compounds found in microalgae and cyanobacteria to extract for applications in skincare, nutrition, and biopharmaceuticals. The company sustainably grows microalgae and cyanobacteria at industrial scale within its photobioreactor facility whereby conditions are optimized for production of these high-value compounds.

Simris Alg’s shares are traded on the Nasdaq First North Growth Market with the short name SIMRIS and ISIN code SE0008091664. Certified Adviser is Amudova AB, telephone: 08-546 017 58, email: info@amudova.se.

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