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Tagrisso with the addition of chemotherapy approved in the EU as new 1st-line treatment for patients with EGFR-mutated advanced lung cancer

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Approval based on FLAURA2 results which showed Tagrisso plus chemotherapy extended median progression-free survival by nearly 9 months vs. standard of care.

AstraZeneca’s Tagrisso (osimertinib) with the addition of pemetrexed and platinum-based chemotherapy has been approved in the European Union (EU) for the 1st-line treatment of adult patients with advanced epidermal growth factor receptor-mutated (EGFRm) non-small cell lung cancer (NSCLC) whose tumours have exon 19 deletions or exon 21 (L858R) mutations.

 

The approval by the European Commission follows the positive opinion of the Committee for Medicinal Products for Human Use and is based on results from the FLAURA2 Phase III trial published in The New England Journal of Medicine. 

 

In the trial, Tagrisso with the addition of chemotherapy reduced the risk of disease progression or death by 38% by investigator assessment compared to Tagrisso monotherapy, which is the 1st-line global standard of care (hazard ratio [HR] 0.62; 95% confidence interval [CI] 0.49-0.79; p<0.0001). Median progression-free survival (PFS) was 25.5 months for patients treated with Tagrisso plus chemotherapy, an 8.8-month improvement versus Tagrisso monotherapy (16.7 months).

 

PFS results from blinded independent central review (BICR) were consistent with the results by investigator assessment, showing 29.4 months median PFS with Tagrisso plus chemotherapy, a 9.5-month improvement over Tagrisso monotherapy (19.9 months) (HR 0.62; 95% CI 0.48-0.80; nominal p=0.0002).

 

Results from a prespecified exploratory analysis of patients in the FLAURA2 trial with brain metastases at baseline showed Tagrisso plus chemotherapy reduced the risk of central nervous system (CNS) disease progression or death by 42% compared to Tagrisso monotherapy (HR 0.58; 95% CI 0.33-1.01) as assessed by BICR. With two years of follow up, 74% of patients treated with Tagrisso plus chemotherapy had not experienced CNS disease progression or death versus 54% of patients treated with Tagrisso monotherapy.

 

While the overall survival (OS) results remained immature at the second interim analysis (41% maturity), a trend towards an OS benefit was observed with Tagrisso plus chemotherapy versus Tagrisso alone (HR 0.75; 95% CI 0.57-0.97), as presented at the 2024 European Lung Cancer Congress. The trial continues to assess OS as a key secondary endpoint.   

 

David Planchard, MD, PhD, Thoracic Oncologist at Gustave Roussy Institute of Oncology and principal investigator for the trial, said: “Today’s news marks a significant advance for patients with EGFR-mutated lung cancer in Europe, providing a new 1st-line treatment option with osimertinib now in combination with chemotherapy. The FLAURA2 results build on the established efficacy of osimertinib monotherapy, showing a meaningful nine-month improvement in progression-free survival and offering physicians the option to tailor treatment to a patient’s specific needs.”

 

Dave Fredrickson, Executive Vice President, Oncology Business Unit, AstraZeneca, said: “This approval reinforces Tagrisso as the backbone therapy in EGFR-mutated lung cancer either as monotherapy or in combination with chemotherapy. This is especially important for those with more aggressive disease, including patients whose cancer has spread to the brain and those with L858R mutations.”

 

The safety profile of Tagrisso plus chemotherapy was consistent with the established profiles of the individual medicines. Adverse event (AE) rates were higher in the Tagrisso plus chemotherapy arm, driven by well-characterised chemotherapy-related AEs. Discontinuation rates of Tagrisso due to AEs were 11% for Tagrisso plus chemotherapy and 6% for monotherapy.   

 

Tagrisso is approved as monotherapy in more than 110 countries including in the US, EU, China and Japan. Approved indications include for 1st-line treatment of patients with locally advanced or metastatic EGFRm NSCLC, locally advanced or metastatic EGFR T790M mutation-positive NSCLC, and adjuvant treatment of early-stage EGFRm NSCLC. Tagrisso with the addition of chemotherapy is also approved in the US, China, Japan and several other countries for the 1st-line treatment of patients with locally advanced or metastatic EGFRm NSCLC. Tagrisso is also currently under review with global regulatory authorities for patients with unresectable, Stage III EGFRm NSCLC based on the LAURA Phase III trial.     

 

Lung cancer

Lung cancer is the leading cause of cancer death among both men and women, accounting for about one-fifth of all cancer deaths.5 Lung cancer is broadly split into NSCLC and small cell lung cancer.3 Each year there are an estimated 2.4 million people diagnosed with lung cancer globally, with 80-85% of patients diagnosed with NSCLC, the most common form of lung cancer.3,5-6

 

In Europe, more than 450,000 people are diagnosed with lung cancer each year.1 Approximately 10-15% of NSCLC patients in the US and Europe, and 30-40% of patients in Asia have EGFRm NSCLC.7-9 Additionally, the majority of patients with NSCLC are diagnosed with advanced disease.4 Patients with EGFRm NSCLC are particularly sensitive to treatment with an EGFR-tyrosine kinase inhibitor (EGFR-TKI) which blocks the cell-signalling pathways that drive the growth of tumour cells.10

 

FLAURA2

FLAURA2 is a randomised, open-label, multi-centre, global Phase III trial in the 1st-line treatment of patients with locally advanced (Stage IIIB-IIIC) or metastatic (Stage IV) EGFRm NSCLC. Patients were treated with Tagrisso 80mg once-daily oral tablets with the addition of chemotherapy (pemetrexed (500mg/m2) plus cisplatin (75mg/m2) or carboplatin (AUC5)) every three weeks for four cycles, followed by Tagrisso with pemetrexed maintenance every three weeks. 

 

The trial enrolled 557 patients in more than 150 centres across more than 20 countries, including in the US, Europe, South America and Asia. The primary endpoint is PFS. The trial is ongoing and will continue to assess the secondary endpoint of OS. 

 

Tagrisso

Tagrisso (osimertinib) is a third-generation, irreversible EGFR-TKI with proven clinical activity in NSCLC, including against CNS metastases. Tagrisso (40mg and 80mg once-daily oral tablets) has been used to treat nearly 800,000 patients across its indications worldwide and AstraZeneca continues to explore Tagrisso as a treatment for patients across multiple stages of EGFRm NSCLC.

 

There is an extensive body of evidence supporting the use of Tagrisso in EGFRm NSCLC. Tagrisso is the only targeted therapy to improve patient outcomes in early-stage disease in the ADAURA Phase III trial, locally advanced stages in the LAURA Phase III trial and late-stage disease in the FLAURA Phase III trial and FLAURA2 Phase III trial. 

 

As part of AstraZeneca’s ongoing commitment to treating patients as early as possible in lung cancer, Tagrisso is also being investigated in the neoadjuvant setting in the NeoADAURA Phase III trial with results expected later this year and in the early-stage adjuvant resectable setting in the ADAURA2 Phase III trial.

 

The Company is also researching ways to address tumour mechanisms of resistance through the SAVANNAH and ORCHARD Phase II trials, and the SAFFRON Phase III trial, which test Tagrisso plus savolitinib, an oral, potent and highly selective MET TKI, as well as other potential new medicines.

 

AstraZeneca in lung cancer

AstraZeneca is working to bring patients with lung cancer closer to cure through the detection and treatment of early-stage disease, while also pushing the boundaries of science to improve outcomes in the resistant and advanced settings. By defining new therapeutic targets and investigating innovative approaches, the Company aims to match medicines to the patients who can benefit most.

 

The Company’s comprehensive portfolio includes leading lung cancer medicines and the next wave of innovations, including Tagrisso and Iressa (gefitinib); Imfinzi (durvalumab) and Imjudo (tremelimumab); Enhertu (trastuzumab deruxtecan) and datopotamab deruxtecan in collaboration with Daiichi Sankyo; Orpathys (savolitinib) in collaboration with HUTCHMED; as well as a pipeline of potential new medicines and combinations across diverse mechanisms of action.

 

AstraZeneca is a founding member of the Lung Ambition Alliance, a global coalition working to accelerate innovation and deliver meaningful improvements for people with lung cancer, including and beyond treatment.

 

AstraZeneca in oncology

AstraZeneca is leading a revolution in oncology with the ambition to provide cures for cancer in every form, following the science to understand cancer and all its complexities to discover, develop and deliver life-changing medicines to patients.

 

The Company’s focus is on some of the most challenging cancers. It is through persistent innovation that AstraZeneca has built one of the most diverse portfolios and pipelines in the industry, with the potential to catalyse changes in the practice of medicine and transform the patient experience.

 

AstraZeneca has the vision to redefine cancer care and, one day, eliminate cancer as a cause of death.

 

AstraZeneca

AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca’s innovative medicines are sold in more than 125 countries and used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on social media @AstraZeneca.

Contacts

For details on how to contact the Investor Relations Team, please click here. For Media contacts, click here.

 

References

  1. Ferlay J, et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer. 2018;103:356-387.
  2. Sanden SV, et al. Prevalence of Epidermal Growth Factor Receptor Exon 20 Insertion Mutations in Non-small-Cell Lung Cancer in Europe: A Pragmatic Literature Review and Meta-analysis. Targeted Onc. 2022;17:153-166.
  3. LUNGevity Foundation. Types of Lung Cancer. Available at: https://lungevity.org/for-patients-caregivers/lung-cancer-101/types-of-lung-cancer. Accessed July 2024.
  4. González M, et al. Overall survival for early and locally advanced non-small-cell lung cancer from one institution: 2000–2017. Clin Transl Oncol 23. 2021;1325–1333
  5. World Health Organization. International Agency for Research on Cancer. Lung Fact Sheet. Available at: https://gco.iarc.who.int/media/globocan/factsheets/cancers/15-trachea-bronchus-and-lung-fact-sheet.pdf. Accessed July 2024.   
  6. Cheema PK, et al. Perspectives on treatment advances for stage III locally advanced unresectable non-small-cell lung cancer. Curr Oncol. 2019;26(1):37-42
  7. Keedy VL, et al. American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients with Advanced Non-Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy. J Clin Oncol. 2011;29:2121-27.
  8. Szumera-Ciećkiewicz A, et al. EGFR Mutation Testing on Cytological and Histological Samples in Non-Small Cell Lung Cancer: a Polish, Single Institution Study and Systematic Review of European Incidence. Int J Clin Exp Pathol. 2013;6:2800-2812. 
  9. Ellison G, et al. EGFR Mutation Testing in Lung Cancer: a Review of Available Methods and Their Use for Analysis of Tumour Tissue and Cytology Samples. J Clin Pathol. 2013;66:79-89.
  10. Cross DA, et al. AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer. Cancer Discov. 2014;4(9):1046-1061.
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aXichem announces the result of the exercise of warrants series TO1A

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aXichem AB (publ) (”aXichem” or the ”Company”) today announces the outcome of the exercise of warrants series TO1A, which were issued in connection with the Company’s rights issue of units in March 2024. A total of 17,862,853 TO1A were exercised, corresponding to approximately 95 percent of the issued warrants, for subscription of 17,862,853 new shares of class A in aXichem. The subscription price per share was SEK 0.95. During the exercise period, the Company received guarantee commitments from a number of a number of qualified investors in the form of a so-called “top-down guarantee” of SEK 2.0 million, corresponding to approximately 11 percent of warrants series TO1A, which was announced on October 16, 2024. Since the subscription rate of warrants series TO1A amounted to approximately 95 percent, the top-down guarantee is claimed for 946,437 shares, corresponding to approximately SEK 0.9 million and approximately 5 percent of the issued warrants series TO1A. In light of this, the Board intends, with the support of the authorization from the annual general meeting on 19 June 2024, to resolve on a directed share issue of 946,437 shares to the guarantors. A separate press release will be published when the Board has resolved on the directed share issue. aXichem will receive approximately SEK 17.0 million before issue costs from the exercise of warrants series TO1A and the Company will further receive approximately SEK 0.9 million before issue costs from the directed share issue to the guarantors that the Board intends to resolve on. aXichem will thus, through the exercise of warrants series TO1A and through the directed share issue to the guarantors, receive a total of approximately SEK 17.9 million before issue costs, corresponding to a subscription rate of 100 percent of TO1A.

In total, 17,862,853 warrants series TO1A were exercised, corresponding to a subscription rate of approximately 95 percent, for subscription of 17,862,853 new shares of class A. Exercised TO1A has been replaced with interim shares pending registration with the Swedish Companies Registration Office. The interim shares are preliminarily expected to be converted to shares of class A during week 45, 2024. aXichem will receive approximately SEK 17.0 million before issue costs through the exercise of warrants series TO1A and will further receive approximately SEK 0.9 million before issue costs from the directed share issue to the guarantors that the Board intends to resolve on. aXichem will thus, through the exercise of TO1A and the directed share issue to the guarantors, receive a total of approximately SEK 17.9 million before issue costs, corresponding to a subscription rate of 100 percent of warrants series TO1A.

The Board intends to resolve on a directed share issue to the guarantors

The Company has previously communicated that, in the event that the guarantee commitments will be utilized, a supplementary directed share issue to the guarantors will be carried out after the exercise period of warrants series TO1A has ended. The result of the exercise of warrants series TO1A means that the top-down guarantee will be claimed. The guarantee means that the guarantors undertake to subscribe for the number of shares that remain in order for the exercise rate of warrants series TO1A to reach 100 percent of the issued warrants.

In light of the above, the Board of aXichem intends, with the support of the authorization from the annual general meeting on 19 June 2024, to resolve on a directed share issue of 946,437 shares to the guarantors, corresponding to approximately SEK 0.9 million and approximately 5 percent of the issued warrants of series TO1A. The subscription price in the directed share issue will, in accordance with the guarantee commitments and what has previously been communicated, be SEK 0.95 per share, which corresponds to the subscription price per share when exercising warrants series TO1A.

A separate press release will be published when the Board has resolved on the directed share issue.

Number of shares, share capital and dilution

Through the exercise of warrants series TO1A, the number of shares in the Company will increase by 17,862,853 shares, from 40,305,615 shares to 58,168,468 shares, and the share capital will increase by 3,572,570.60 SEK, from SEK 8,061,123 to 11,633,693.60 SEK, corresponding to a dilution of approximately 31 percent.

For more information:

Torsten Helsing, CEO, aXichem AB

Phone: +46 706 863 355, Email: torsten.helsing@axichem.com

Certified adviser for aXichem is Västra Hamnen Corporate Finance AB.

The information was submitted, through the agency of the above contact person, for publication on October 23, 2024, at 09:00 CEST.

About aXichem

aXichem develops, patents and markets natural analogue industrial chemicals, i.e., synthetically produced substances that have similar and comparable properties to natural substances. The company’s first product is phenylcapsaicin, which the company commercializes under two brands, aXiphen® and aXivite®, as an ingredient in animal feed and dietary supplements, respectively. The business is divided into three market areas with different applications for phenylcapsaicin: as an ingredient in feed for poultry, such as chicken and turkey, as an ingredient in food supplements for gut health, weight control and sports and exercise, and as an ingredient in food supplements for the bio-enhancement of curcumin and melatonin. aXichem is listed on the Nasdaq First North Growth Market. More information is available at www.axichem.com.

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aXichem offentliggör utfall av utnyttjande av teckningsoptioner serie TO1A

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aXichem AB (publ) (“aXichem” eller “Bolaget”) meddelar idag utfallet från utnyttjandet av teckningsoptionerna serie TO1A, vilka emitterades i samband med Bolagets företrädesemission av units i mars 2024. Totalt utnyttjades 17 862 853 TO1A, motsvarande en teckningsgrad om cirka 95 procent, för teckning av 17 862 853 nya A-aktier i aXichem. Teckningskursen per aktie var 0,95 SEK. Under utnyttjandeperioden erhöll Bolaget garantiåtaganden från ett antal kvalificerade investerare i form av en så kallad toppgaranti om 2,0 MSEK, motsvarande cirka 11 procent av emissionsvolymen i TO1A, vilket offentliggjordes den 16 oktober 2024. Eftersom teckningsgraden uppgick till cirka 95 procent, tas toppgarantin i anspråk om 946 437 aktier, motsvarande cirka 0,9 MSEK och cirka 5 procent av emissionsvolymen i TO1A. Mot bakgrund av detta avser styrelsen, med stöd av bemyndigandet från årsstämman den 19 juni 2024, besluta om en riktad nyemission av 946 437 aktier till garanterna. Styrelsens beslut om riktad nyemission kommer offentliggöras i ett separat pressmeddelande när styrelsen fattat sådant beslut. aXichem tillförs genom TO1A cirka 17,0 MSEK före emissionskostnader och kommer att tillföras ytterligare cirka 0,9 MSEK före emissionskostnader genom den riktade nyemissionen till garanterna som styrelsen avser besluta om. aXichem kommer därmed, genom TO1A och den riktade nyemissionen till garanterna, totalt att tillföras cirka 17,9 MSEK före emissionskostnader, motsvarande en teckningsgrad om 100 procent av TO1A.

Totalt utnyttjades 17 862 853 TO1A, motsvarande en teckningsgrad om cirka 95 procent, för teckning av 17 862 853 nya A-aktier. Utnyttjade TO1A har ersatts med interimsaktier i väntan på registrering hos Bolagsverket. Interimsaktierna förväntas preliminärt konverteras till A-aktier under vecka 45, 2024. aXichem tillförs genom utnyttjandet av TO1A cirka 17,0 MSEK före emissionskostnader och kommer att tillföras ytterligare cirka 0,9 MSEK före emissionskostnader genom den riktade nyemissionen till garanterna som styrelsen avser besluta om. aXichem kommer därmed, genom TO1A och den riktade nyemissionen till garanterna, totalt att tillföras cirka 17,9 MSEK före emissionskostnader, motsvarande en teckningsgrad om 100 procent av TO1A.

Styrelsen avser besluta om riktad nyemission till garanterna

Bolaget har tidigare kommunicerat att för det fall garantiåtagandena tas i anspråk kommer det att genomföras en kompletterande riktad nyemission av aktier till garanterna efter att nyttjandeperioden för TO1A avslutats. Utfallet för utnyttjande av TO1A innebär att toppgarantin tas i anspråk. Toppgarantin innebär att garanterna åtar sig att teckna det antal aktier som återstår för att utnyttjandegraden ska uppgå till 100 procent av emissionsvolymen av teckningsoptionerna serie TO1A.

Styrelsen för aXichem avser mot bakgrund av ovan, med stöd av bemyndigandet från årsstämman den 19 juni 2024, besluta om en riktad nyemission av 946 437 aktier till garanterna, motsvarande cirka 0,9 MSEK och cirka 5 procent av emissionsvolymen i TO1A. Teckningskursen i den riktade nyemission kommer, i enlighet med garantiavtalen och vad som tidigare kommunicerats, vara 0,95 SEK per aktie, vilket motsvarar teckningskursen per aktie vid utnyttjande av TO1A.

Styrelsens beslut om riktad nyemission kommer offentliggöras i ett separat pressmeddelande när styrelsen fattat sådant beslut.

Antal aktier, aktiekapital och utspädning

Genom utnyttjandet av TO1A ökar antalet aktier i Bolaget med 17 862 853 aktier, från 40 305 615 aktier till 58 168 468 aktier, och aktiekapitalet ökar med 3 572 570,60 SEK, från 8 061 123 SEK till 11 633 693,60 SEK, motsvarande en utspädningseffekt om cirka 31 procent.

För mer information:

Torsten Helsing, VD, aXichem AB

Tel: +46 706 86 33 55 E-post: torsten.helsing@axichem.com

Certified adviser åt aXichem är Västra Hamnen Corporate Finance AB.

Informationen lämnades, genom ovanstående kontaktpersons försorg, för offentliggörande den 23 oktober 2024 kl. 09:00 CEST.

Om aXichem 

aXichem utvecklar, patenterar och marknadsför naturanaloga industrikemikalier, det vill säga syntetiskt framställda substanser som har likartade och jämförbara egenskaper som naturliga substanser. Bolagets första produkt är phenylcapsaicin, som Bolaget kommersialiserar under två varumärken, aXiphen® och aXivite®, som ingrediens i djurfoder respektive kosttillskott. Verksamheten är uppdelad i tre marknadsområden med olika applikationer för phenylcapsaicin: som ingrediens i foder för fjäderfän, så som kyckling och kalkon; som ingrediens i kosttillskott för tarmhälsa, viktkontroll samt sport och träning; samt som ingrediens i kosttillskott för biotillgänglighetsförstärkning av curcumin och melatonin. aXichem är listat på Nasdaq First North Growth Market.
Mer information finns på www.axichem.com

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Gympak och Centrovital Berlin lanserar samarbete med innovativ fitnesslösning för hotellgäster

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Det fyrstjärniga superiorhotellet har officiellt blivit det första hotellet i Tyskland att erbjuda Gympaks innovativa lösningar. Detta samarbete introducerar möjligheten för gäster att låna träningskläder och fitnessutrustning direkt till sina rum, vilket ytterligare förbättrar hotellets redan imponerande spa- och gymfaciliteter.

Hotellet har 158 välutrustade rum och erbjuder omfattande hälso- och välbefinnandetjänster, inklusive en 25-meters simbassäng, ett toppmodernt gym och en generös spaanläggning. Det är nu det första hotellet i Tyskland som samarbetar med Gympak, vilket gör det möjligt för gäster att hyra träningskläder och utrustning direkt till sina rum, och därigenom förhöja sin träningsupplevelse under vistelsen. Detta samarbete syftar till att öka gästnöjdheten genom att göra fitnesstjänster mer tillgängliga och bekväma.
 

Viktor Weinbender, Front Office Manager på Centrovital Hotel Berlin, uttryckte sin entusiasm över samarbetet: ”Vi är glada att kunna erbjuda Gympaks banbrytande fitnesstjänst till våra gäster. Det ger en ny nivå av bekvämlighet, vilket gör att våra gäster kan vara aktiva oavsett var de befinner sig på hotellet, inklusive från bekvämligheten av sina egna rum.”

Tar hotellfitness till nya höjder
Detta samarbete markerar en spännande utveckling i Gympaks uppdrag att tillhandahålla tillgängliga och bekväma fitnesslösningar för hotell över hela Europa. Tjänsten är utformad för att öka gästnöjdheten genom att erbjuda ett smidigt sätt för gäster att upprätthålla sina träningsrutiner under resan. Med Centrovital Berlin i spetsen är Gympak redo att expandera sin närvaro och ge fler hotell i Tyskland verktygen för att revolutionera sina gästers upplevelse.
 


 

Stephan Wachsmuth, hotellets General Manager, delade sina tankar: ”Vårt mål är att erbjuda en förstklassig fitnessupplevelse för våra gäster. Genom att samarbeta med Gympak kan vi förbättra våra fitnesstjänster och stödja våra gäster i att upprätthålla sin hälsa och sitt välbefinnande under hela vistelsen. Detta initiativ är särskilt värdefullt för våra affärsresenärer, seminarie- och konferensdeltagare, samt våra wellness-gäster. De kan utnyttja de omfattande faciliteterna i vårt exceptionella Spa och Sports Club i Berlin-Spandau, som har en stor medlemsbas. Genom vårt omfattande kursprogram har gästerna också flexibiliteten att spontant delta i pass under sitt besök, vilket ytterligare berikar deras vistelse hos oss.”

Gympaks VD, Jone Sølvik, kommenterade expansionen: ”Vi är otroligt tacksamma för det förtroende Centrovital har visat oss. Detta partnerskap markerar vårt inträde på den tyska marknaden, och vi ser fram emot att göra en verklig skillnad här. Vi ser fram emot att se hur gästerna reagerar på denna nya nivå av bekvämlighet, och vi är övertygade om att det kommer leda till många ’wow’-ögonblick.”
 


 

Gäster kan nu njuta av en unik fitnessupplevelse i Berlin, oavsett om de väljer att träna på gymmet, i spat eller direkt på sina hotellrum med Gympaks tjänster. Detta innovativa erbjudande hjälper gäster att prioritera sin hälsa och sitt välbefinnande, vilket gör det möjligt för dem att hålla sig aktiva medan de njuter av alla bekvämligheter som hotellet har att erbjuda.

För mer information:
Jone Sølvik, VD Gympak, jone.solvik@gympak.com+46 706 112 100
Stephan Wachsmuth, General Manager, swachsmuth@centrovital-berlin.de
Viktor Weinbender, Front Office Manager, vweinbender@centrovital-berlin.de

Om Gympak:
Gympak är ett svenskt företag som erbjuder innovativa wellness-lösningar för hotell. Företaget gör det enkelt för hotellgäster att ta hand om sin hälsa genom att erbjuda träningsutrustning, kläder och personliga träningsprogram som kan nyttjas direkt på hotellrummet.

Om Centrovital:
År 2004, efter flera års renovering, öppnades den kulturmärkta byggnaden på Brauereihof nr. 6 under namnet ”Centrovital”. Beläget i Berlins City West, nära Havel, kombinerar Centrovital nu ett hotell, ett Spa & Sports Club, ett Day Spa & Ayurveda Centre, och ett brett utbud av gastronomiska alternativ under ett tak. Gäster kan förvänta sig 158 moderna rum och sviter, tolv multifunktionella eventrum för affärs- och privata evenemang, Emil’s Restaurant med en rymlig terrass, La Havanita Bar & Bistro, och en Rooftop Bar.

Centrovital Spa och Sports Club för gäster och medlemmar erbjuder multimedia Technogym®-utrustning, Functional Tower, SKILLMILL™, Kinesis® track, Galileo® vibrationsträning, personlig träning och ett varierat kursprogram. ”SCANECA”, ett revolutionerande holistiskt 3D-kroppsanalys system ”Made in Germany”, är också tillgängligt. Med hjälp av en detaljerad 3D-avatar mäts relevanta kroppsomfång snabbt och exakt, hållning analyseras och en detaljerad rapport över de viktigaste hälsorelaterade kroppsvärdena skapas. SCANECA-teknologin utvecklades under tre års forsknings- och utvecklingsarbete i Berlin av ett team av vetenskapsmän och experter i samarbete med Humboldt-Innovation vid Humboldtuniversitetet i Berlin. SCANECA-teamet hedrades av ”Stifterverband” för denna unika innovation.

I spa- och bastuområdet inbjuder en 25-meters pool, bubbelpool, fem bastur och takterrassen till avkoppling. Isigloon kyler dig efter bastubadet. I det närliggande Ayurveda Centre kan du njuta av ett omfattande urval av traditionella ayurvediska behandlingar; Day Spa erbjuder klassiska wellness- och skönhetsbehandlingar.

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