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Lynparza reduced the risk of cancer recurrence by 42% in the adjuvant treatment of patients with germline BRCA-mutated high-risk early breast cancer in OlympiA Phase III trial

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First medicine targeting BRCA mutations to show clinical benefit in adjuvant setting

Results from the OlympiA Phase III trial showed AstraZeneca and MSD’s Lynparza (olaparib) demonstrated a statistically significant and clinically meaningful improvement in invasive disease-free survival (iDFS) versus placebo in the adjuvant treatment of patients with germline BRCA-mutated (gBRCAm) high-risk human epidermal growth factor receptor 2 (HER2)-negative early breast cancer.

The results will be presented during the plenary session of the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting on 6 June 2021 (abstract LBA#1) and were published today in The New England Journal of Medicine.

An estimated 2.3 million people were diagnosed with breast cancer worldwide in 2020 and BRCA mutations are found in approximately 5% of breast cancer patients.1,2

Sue Friedman, Executive Director, Facing Our Risk of Cancer Empowered (FORCE) and member of the OlympiA trial steering committee, said: “While there have been great strides in the early treatment of breast cancer, the fear of cancer returning is still at the forefront of patients’ minds. New targeted treatment approaches are needed in the adjuvant setting that can help keep cancer and that fear at bay.”

Andrew Tutt, chair of the OlympiA trial steering committee and professor of Oncology at The Institute of Cancer Research, London and Kings College London, said: “We are thrilled that our global academic and industry partnership in OlympiA has been able to help identify a possible new treatment option for patients with early-stage breast cancer and who have inherited mutations in their BRCA1 or BRCA2 genes. Patients with early-stage breast cancer who have inherited BRCA mutations are typically diagnosed at a younger age compared to those without such a mutation. Olaparib has the potential to be used as a follow-on to all the standard initial breast cancer treatments to reduce the rate of life-threatening recurrence and cancer spread for many patients identified through genetic testing to have mutations in these genes.”

Dave Fredrickson, Executive Vice President, Oncology Business Unit, said: “This is the first time that any medicine targeting a BRCA mutation has demonstrated the potential to change the course of early-stage breast cancer and offer hope for a cure. By providing a treatment which significantly reduces the risk of breast cancer returning in these high-risk patients, we hope Lynparza will set a new benchmark demonstrating sustained clinical benefit. We are working with regulatory authorities to bring Lynparza to these patients as quickly as possible.”

Roy Baynes, Senior Vice President and Head of Global Clinical Development, Chief Medical Officer, MSD Research Laboratories, said: “Results of the OlympiA trial represent a potential step forward for patients with high-risk early breast cancer. These new data support the importance of testing at diagnosis for BRCA1/2 mutations, which are actionable biomarkers that can help identify patients with early breast cancer who may be eligible for adjuvant treatment with Lynparza. Testing for BRCA mutations in addition to hormone receptor status and the expression of the HER2 protein will allow clinicians to better inform potential treatment plans for their patients.”

In the overall trial population of patients who had completed local treatment and standard neoadjuvant or adjuvant chemotherapy, results showed Lynparza reduced the risk of invasive breast cancer recurrences, second cancers or death by 42% (based on a hazard ratio [HR] of 0.58; 99.5% confidence interval [CI] 0.41-0.82; p<0.0001). At three years, 85.9% of patients treated with Lynparza remained alive and free of invasive breast cancer and second cancers versus 77.1% on placebo.

Lynparza also demonstrated a statistically significant and clinically meaningful improvement in the key secondary endpoint of distant disease-free survival (DDFS) in the overall trial population. Lynparza reduced the risk of distant disease recurrence or death by 43% (based on an HR of 0.57; 99.5% CI 0.39-0.83; p<0.0001). At the time of this initial data cut-off, fewer deaths had occurred in patients receiving Lynparza, but the difference in overall survival (OS) did not reach statistical significance. The trial will continue to assess OS as a secondary endpoint.

In February 2021, the Independent Data Monitoring Committee recommended for the OlympiA trial to move to early primary analysis and reporting. Based on the planned interim analysis, the IDMC concluded that the trial crossed the superiority boundary for its primary endpoint of iDFS and demonstrated a sustainable and clinically relevant treatment effect for Lynparza versus placebo.

Summary of OlympiA results

Lynparza(n=921) Placebo(n=915)
iDFS (primary endpoint)
HR (99.5% CI) 0.58 (0.41, 0.82)
p-value p<0.0001
iDFS rates
One year 93.3% 88.4%
Two years 89.2% 81.5%
Three years 85.9% 77.1%
DDFS (secondary endpoint)
HR (99.5% CI) 0.57 (0.39, 0.83)
p-value p<0.0001
DDFS rates
One year 94.3% 90.2%
Two years 90.0% 83.9%
Three years 87.5% 80.4%
OS at interim (secondary endpoint)ii
HR (99% CI) 0.68 (0.44, 1.05)
p-value p=0.024
OS rates
One year 98.1% 96.9%
Two years 94.8% 92.3%
Three years 92.0% 88.3%

i The data cut-off date for the interim analysis was 27 March 2020.

ii Statistical significance not reached based on the interim analysis plan for alpha conservation for future survival analyses.

The safety and tolerability profile of Lynparza in this trial was in line with that observed in prior clinical trials. The most common adverse events (AEs) were nausea (57%), fatigue (40%), anaemia (23%) and vomiting (23%). Grade 3 or higher AEs were anaemia (9%), neutropenia (5%), leukopenia (3%), fatigue (2%), and nausea (1%). Approximately 10% of patients treated with Lynparza discontinued treatment early due to AEs.

OlympiA is a global collaborative Phase III trial coordinated by the Breast International Group (BIG) worldwide, in partnership with NRG Oncology, the US National Cancer Institute (NCI), Frontier Science & Technology Research Foundation (FSTRF), AstraZeneca and MSD.3 The trial is sponsored by NRG Oncology in the US and by AstraZeneca outside the US.

Lynparza is approved in the US, Japan, and a number of other countries for gBRCAm, HER2-negative, metastatic breast cancer previously treated with chemotherapy; in the EU, this includes locally advanced breast cancer.

Early breast cancer

Breast cancer is the most common cancer among women worldwide and an estimated 70% of all breast cancer is diagnosed at an early stage.4,5 Breast cancer is one of the most biologically diverse tumour types with various factors underlying its development and progression.6 The discovery of biomarkers in the development of breast cancer has greatly impacted scientific understanding of the disease and treatment of patients who develop the disease.7

OlympiA

OlympiA is a Phase III, double-blind, placebo-controlled, multicentre trial testing the efficacy and safety of Lynparza tablets versus placebo as adjuvant treatment in patients with gBRCAm, high-risk, HER2-negative early breast cancer, who have completed definitive local treatment and neoadjuvant or adjuvant chemotherapy. The primary endpoint of the trial is iDFS defined as time from randomisation to date of first loco-regional or distant recurrence, new cancer or death from any cause. Key secondary endpoints include OS and DDFS, which is defined as time from randomisation until documented evidence of first distant recurrence of breast cancer or death without distant recurrence.3

BIG

The Breast International Group (BIG) is an international not-for-profit organisation for academic breast cancer research groups from around the world, based in Brussels, Belgium.

Founded by leading European opinion leaders in 1999, the organisation aims to address fragmentation in breast cancer research and now represents a network of over 50 like-minded research groups affiliated with specialised hospitals, research centres and leading experts across approximately 70 countries on six continents.

BIG’s research is supported in part by its philanthropy unit, known as BIG against breast cancer, which is used to interact with the general public and donors, and to raise funds for BIG’s purely academic breast cancer trials and research programmes.

FSTRF

Frontier Science & Technology Research Foundation (FSTRF) is a non-profit, research organisation which supports research networks, pharmaceutical companies and investigators to conduct scientifically meaningful high-quality clinical trials. The OlympiA trial involved research staff in the US and in the Affiliate office in Scotland.          

FSTRF works with scientists and technicians in more than 800 laboratories, universities and medical centres around the world to provide a comprehensive range of research services throughout the clinical trial process including design, analysis and reporting.          

Through its work, FSTRF aims to advance the application of statistical science and practice and data management techniques in science, healthcare and education. 

NRG Oncology

NRG Oncology is a network group funded by the US National Cancer Institute (NCI), a part of the National Institutes of Health. NRG Oncology brings together the National Surgical Adjuvant Breast and Bowel Project (NSABP), the Radiation Therapy Oncology Group (RTOG), and the Gynecologic Oncology Group (GOG), with the mission to improve the lives of cancer patients by conducting practice-changing multi-institutional clinical and translational research. NRG Oncology sponsored OlympiA in the US and collaborated with the other adult cancer clinical trials research groups funded by the NCI, Alliance, ECOG/ACRIN and the Southwest Oncology Group. The NCI and AstraZeneca are collaborating under a Cooperative Research and Development Agreement between the parties.

BRCA1 and BRCA2

BRCA1 and BRCA2 are human genes that produce proteins responsible for repairing damaged DNA and play an important role maintaining the genetic stability of cells. When either of these genes is mutated or altered such that its protein product either is not made or does not function correctly, DNA damage may not be repaired properly, and cells become unstable. As a result, cells are more likely to develop additional genetic alterations that can lead to cancer and confer sensitivity to PARP inhibitors including Lynparza.8-11

Lynparza

Lynparza (olaparib) is a first-in-class PARP inhibitor and the first targeted treatment to block DNA damage response (DDR) in cells/tumours harbouring a deficiency in homologous recombination repair (HRR), such as mutations in BRCA1 and/or BRCA2. Inhibition of PARP with Lynparza leads to the trapping of PARP bound to DNA single-strand breaks, stalling of replication forks, their collapse and the generation of DNA double-strand breaks and cancer cell death. Lynparza is being tested in a range of PARP-dependent tumour types with defects and dependencies in the DDR pathway.

Lynparza is currently approved in a number of countries, including those in the EU, for the maintenance treatment of platinum-sensitive relapsed ovarian cancer. It is approved in the US, the EU, Japan, China, and several other countries as 1st-line maintenance treatment of BRCA-mutated advanced ovarian cancer following response to platinum-based chemotherapy. It is also approved in the US, EU and Japan as a 1st-line maintenance treatment with bevacizumab for patients with HRD-positive advanced ovarian cancer (BRCAm and/or genomic instability). Lynparza is approved in the US, Japan, and a number of other countries for germline BRCA-mutated, HER2-negative, metastatic breast cancer, previously treated with chemotherapy; in the EU, this includes locally advanced breast cancer. It is also approved in the US, the EU, Japan and several other countries for the treatment of germline BRCAm metastatic pancreatic cancer. Lynparza is approved in the US for HRR gene-mutated metastatic castration-resistant prostate cancer (BRCAm and other HRR gene mutations) and in the EU and Japan for BRCAm metastatic castration-resistant prostate cancer. Regulatory reviews are underway in several countries for ovarian, breast, pancreatic and prostate cancers.

Lynparza, which is being jointly developed and commercialised by AstraZeneca and MSD, has been used to treat over 40,000 patients worldwide. Lynparza has the broadest and most advanced clinical trial development programme of any PARP inhibitor, and AstraZeneca and MSD are working together to understand how it may affect multiple PARP-dependent tumours as a monotherapy and in combination across multiple cancer types. Lynparza is the foundation of AstraZeneca’s industry-leading portfolio of potential new medicines targeting DDR mechanisms in cancer cells.

The AstraZeneca and MSD strategic oncology collaboration

In July 2017, AstraZeneca and Merck & Co., Inc., Kenilworth, NJ, US, known as MSD outside the US and Canada, announced a global strategic oncology collaboration to co-develop and co-commercialise Lynparza, the world’s first PARP inhibitor, and Koselugo (selumetinib), a mitogen-activated protein kinase (MEK) inhibitor, for multiple cancer types. Working together, the companies will develop Lynparza and Koselugo in combination with other potential new medicines and as monotherapies. Independently, the companies will develop Lynparza and Koselugo in combination with their respective PD-L1 and PD-1 medicines.

AstraZeneca in breast cancer

Driven by a growing understanding of breast cancer biology, AstraZeneca is starting to challenge, and redefine, the current clinical paradigm for how breast cancer is classified and treated to deliver even more effective treatments to patients in need – with the bold ambition to one day eliminate breast cancer as a cause of death.

AstraZeneca has a comprehensive portfolio of approved and promising compounds in development that leverage different mechanisms of action to address the biologically diverse breast cancer tumour environment. AstraZeneca aims to continue to transform outcomes for HR-positive breast cancer with foundational medicines Faslodex (fulvestrant) and Zoladex (goserelin) and the next-generation SERD and potential new medicine camizestrant. PARP inhibitor, Lynparza (olaparib) is a targeted treatment option for metastatic breast cancer patients with an inherited BRCA mutation. AstraZeneca with MSD continue to research Lynparza in metastatic breast cancer patients with an inherited BRCA mutation and are exploring new opportunities to treat these patients earlier in their disease state.

Building on the first approval of Enhertu (trastuzumab deruxtecan), a HER2-directed antibody-drug conjugate (ADC), in previously treated HER2-positive metastatic breast cancer, AstraZeneca and Daiichi Sankyo are exploring its potential in earlier lines of treatment and in new breast cancer settings. To bring much needed treatment options to patients with triple-negative breast cancer, an aggressive form of breast cancer, AstraZeneca is testing immunotherapy Imfinzi (durvalumab) in combination with other oncology medicines, including Lynparza and Enhertu, assessing the potential of AKT kinase inhibitor, capivasertib, in combination with chemotherapy, and collaborating with Daiichi Sankyo to explore the potential of TROP2-directed ADC, datopotamab deruxtecan.

AstraZeneca in oncology

AstraZeneca is leading a revolution in oncology with the ambition to provide cures for cancer in every form, following the science to understand cancer and all its complexities to discover, develop and deliver life-changing medicines to patients.

The Company’s focus is on some of the most challenging cancers. It is through persistent innovation that AstraZeneca has built one of the most diverse portfolios and pipelines in the industry, with the potential to catalyse changes in the practice of medicine and transform the patient experience.

AstraZeneca has the vision to redefine cancer care and, one day, eliminate cancer as a cause of death.

AstraZeneca
AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines in Oncology and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on Twitter @AstraZeneca.

Contacts

For details on how to contact the Investor Relations Team, please click here. For Media contacts, click here.

References

1. World Health Organization. Estimated number of cases in 2020, worldwide, both sexes, all ages. Available at: https://gco.iarc.fr/today/data/factsheets/cancers/20-Breast-fact-sheet.pdf. Accessed May 2021.

2. Mitri Z, et al. The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy. Chemother Res Pract. 2012;743193.

3. ClinicalTrials.gov. Olaparib as Adjuvant Treatment in Patients with Germline BRCA-mutated High Risk HER2 Negative Primary Breast Cancer (OlympiA). Available at clinicaltrials.gov/ct2/show/NCT02032823. Accessed May 2021.

4. Breast Cancer School. Will I survive breast cancer? Available at: https://www.breastcancercourse.org/will-i-survive-breast-cancer/. Accessed May 2021.

5. Bertozzi S, et al. Biomarkers in Breast Cancer. Intechopen. 2018.

6. Yersal O, and Barutca S. Biological Subtypes of Breast Cancer: Prognostic and therapeutic implications. World J Clin Oncol. 2014;5(3):412-424.

7. Rivenbark A, et al. Molecular and Cellular Heterogeneity in Breast Cancer: Challenges for Personalized Medicine. Am J Pathol. 2013;183(4):1113-1124.

8. Roy R, et al. BRCA1 and BRCA2: Different Roles in a Common Pathway of Genome Protection. Nat Rev Cancer. 2021;12(1):68–78.

9. Wu J, et al. The Role of BRCA1 in DNA Damage Response. Protein Cell. 2010;1(2):117-11.

10. Gorodetska I, et al. BRCA Genes: The Role in Genome Stability, Cancer Stemness and Therapy Resistance. J Cancer. 2019;10(9):2109-2127.

11. Li H, et al. PARP Inhibitor Resistance: The Underlying Mechanisms and Clinical Implications. Mol Cancer. 2020;19:107.

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Regeringen föreslår lättnader i byggkraven för studentbostäder

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Regeringen har beslutat om en lagrådsremiss med förslag till lättnader i byggkraven för studentbostäder. Syftet är att öka möjligheterna till flexibilitet vid byggandet.

– På många studieorter är det svårt för studenter att hitta boende. Därför behöver byggregelverket förenklas. Syftet är att möjliggöra för fler studentbostäder genom sänkta byggkostnader och ökad flexibilitet, säger infrastruktur- och bostadsminister Andreas Carlson.

Förslaget innebär att det blir möjligt att göra undantag från kraven på tillgänglighet och användbarhet i en byggnad som innehåller studentbostäder. Undantagen ska kunna tillämpas vid både nyproduktion och vid ändring av en byggnad.

Det ska vara möjligt att göra undantag för högst 80 procent av studentbostäderna i ett byggprojekt. Minst 20 procent av studentbostäderna ska fortfarande uppfylla gällande krav på tillgänglighet och användbarhet för personer med nedsatt rörelse- eller orienteringsförmåga.

Lagändringen ger större flexibilitet vid byggande av studentbostäder och skapar fler tänkbara sätt att utforma planlösningar. Till exempel kan bostadsytan minskas och fler bostäder rymmas inom en given yta.  

De föreslagna undantagen ska inte hindra personer med funktionsnedsättning att vara delaktiga i sociala sammanhang. En studentbostad som omfattas av undantagen ska kunna besökas av en person med nedsatt rörelse- eller orienteringsförmåga.

Regeringen breddar också definitionen av studentbostäder till att inkludera all vuxenutbildning för att göra det möjligt för fler kommuner att erbjuda studentbostäder.

Förslagen föreslås träda i kraft den 1 juli 2025.

Lagrådsremissen: Lättnader i byggkraven för studentbostäder – Regeringen.se

Presskontakt
Ebba Gustavsson
Pressekreterare hos infrastruktur- och bostadsminister Andreas Carlson
Telefon (växel) 08-405 10 00
Mobil 076-12 70 488
ebba.gustavsson@regeringskansliet.se

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“Vi behöver tillsammans enas om vettiga avtal, som sätter standard för branschen”

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Sveriges Radios Kulturnytt gör just nu en mycket välkommen granskning av villkoren i musikbranschen. Igår lyftes artisten Siw Malmkvists situation med ett avtal som inte förnyats på över 60 år. Hennes situation är tyvärr långt ifrån unik. Musikerförbundet har länge uppmärksammat att majorbolagen fortsätter att betala extremt låga royaltynivåer till artister vars kontrakt skrevs på 1960-talet – en tid då digital streaming inte existerade. 

– Jag kan intyga att artisterna som talar ut i P1 är långt ifrån ensamma om sin situation och vi uppmanar deras artistkollegor att gå ut med sitt tydliga stöd till de som vågar bryta tystnaden om oskäliga ersättningar, säger Musikerförbundets ordförande Karin Inde. 

Musiker och artister skapar det värde som skivbolagen tjänar pengar på, men ändå ser vi gång på gång hur bolagen behåller stora delar av intäkterna. Att en av Sveriges mest folkkära artister, med en karriär som sträcker sig över decennier, fortfarande har en oskälig royalty är ett tydligt bevis på branschens obalans. 

– Tystnadskulturen kring prissättning är enbart bra för bolagen. Både artister och musiker skulle verkligen tjäna på att dela med sig till varandra om hur betalningar och dealar verkligen ser ut. Förstås i trygga, egna rum. Det är bara bolagen som tjänar på att vi inte pratar med varandra om pengar, säger Karin Inde. 

Stort tack till de modiga artister som ser till att lyfta problematiken! För att vi ska få till en i grunden mer rättvis musikbransch behöver de stora parterna i sammanhanget – skivbolagen, musikerna och artisterna – göra som de flesta andra svenska branscher lyckas med:  

– Vi behöver tillsammans enas om vettiga och balanserade avtal, som sätter standard för branschen. Musikerförbundet är redo att göra vår del i arbetet för bättre villkor i musikbranschen, frågan är om skivbolagen är redo, säger Karin Inde.  

Karin Inde
Förbundsordförande
karin.inde@musikerforbundet.se
+46 (0)704447228

Musikerförbundet är fackförbundet för professionella musiker och artister. Vi arbetar för förbättrade upphovsrättsliga och arbetsrättsliga villkor och för att våra medlemmar ska få en rättvis del av de värden de skapar i samhället.

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Bönor från egen kaffeskog, sump till jord – Viking Lines nya kaffe gör gott på många olika sätt

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Viking Lines resenärer dricker varje år 8,5 miljoner koppar kaffe. Nu satsar rederiet på ett helt nytt kaffe som ger minskade klimatutsläpp och bättre levnadsvillkor för odlarna. Kaffet från Slow Forest odlas på rederiets egen odling i Laos utan kemiska gödningsmedel, handplockas och rostas därefter i Danmark.

Allt kaffe som serveras på Viking Lines fartyg är nu hållbart producerat Slow Forest-kaffe, odlat på rederiets 75 hektar stora odling på högplatåerna i Laos och rostat i Danmark. Kaffeplantorna odlas bland träd på återbeskogad mark, i stället för på traditionellt skövlade plantager. Viking Lines odling ligger i en kolsänka där målsättningen är att plantera 30 000 träd, vilket innebär nästan 400 träd per hektar. Kaffeskogen förbättrar också den lokala biologiska mångfalden i området.

Odlingen, bearbetningen och rostningen av kaffet hanteras av Slow Forest Coffee. För företaget är det viktigt att produktionskedjan är rättvis och transparent. Utöver miljöfördelarna erbjuder Slow Forest bättre lönevillkor och sjukersättning för byns odlare.

”Den traditionella kaffetillverkningens koldioxidavtryck är stort och merparten av intäkterna går till Europa i stället för produktionsländerna. Vi ville göra annorlunda. Våra kunder vill göra hållbara val, och nu kan de njuta av sitt kaffe med bättre samvete än någonsin tidigare,” berättar Viking Lines restaurangchef Janne Lindholm.

Bönorna till Slow Forest-kaffet får sakta mogna i skuggan av träden, utan kemiska gödningsmedel. De plockas också för hand, vilket avsevärt förbättrar kaffets kvalitet och smak. Viking Lines nya kaffe består till 100 procent av Arabica-bönor, med en balanserad syrlighet samt smak av nötter och choklad. Rostningsprofilen har skapats av den världsberömda danska rostningsmästaren Michael de Renouard.

”Vi valde en mörkrost till fartygets kaffe, vilket passar både finländarnas och svenskarnas nuvarande smakpreferenser gällande rostning. Finländarnas smak gällande kaffe har under de senaste åren utvecklats mot en mörkare rostning. Innan vi gjorde vårt slutgiltiga val testades det nya kaffet i Viking Cinderellas bufférestaurang och personalmässen – och båda testgrupperna gav toppbetyg. Då 8,5 miljoner koppar kaffe bryggs varje år kan inget lämnas åt slumpen!” säger Janne Lindholm.

Viking Lines hållbarhetsmål stannar inte vid produktionskedjan. Kaffesump från fartygen återvinns nämligen som råmaterial för trädgårdsjord. Detta minskar avsevärt användningen av jungfrulig torv vid tillverkningen av mylla.

”Vi har som mål att allt som tagits ombord på fartygen som är möjligt att återvinna ska återanvändas eller återvinnas. Det gäller inte bara kaffet utan även matavfall och till exempel textilier som tas ur bruk. Ett bra exempel på vårt livscykeltänkande är att frityrolja från fartygets restauranger blir till biobränsle för den finska sjöfartsindustrin,” säger Viking Lines hållbarhetschef Dani Lindberg.

Slow Forest Coffee – 5 fakta:

  1. Slow Forest Coffee är ett kaffeföretag som verkar i Laos, Vietnam och Indonesien i samarbete med över 500 lokala kaffeodlare.
  2. Företaget grundades år 2019 av Pinja Puustjärvi, driven av en vilja att skydda skogarna i Laos och stötta lokala odlare. Puustjärvi bodde som barn i Laos på grund av sin fars arbete.
  3. Kaffet odlas i restaurerade kaffeskogar, som binder stora mängder kol och ökar den biologiska mångfalden.
  4. Det är viktigt för företaget att produktionskedjan är ansvarsfull och transparent, samt att verksamheten gynnar både miljön och de lokala samhällena.
  5. Slow Forest Coffee betalar odlarna bättre ersättning än genomsnittet i Laos och erbjuder förmåner som underlättar deras liv: förskottsbetalningar, utbildning och möjligheten att låna pengar från en krisfond.

Mera infomation om Slow Forest Coffee här

Tilläggsinformation:

Janne Lindholm, restaurangchef

janne.lindholm@vikingline.com, tel. +358 400 744 806

Dani Lindberg, hållbarhetschef

dani.lindberg@vikingline.com, tel. +358 18 27 000

Johanna Boijer-Svahnström, informationsdirektör

johanna.boijer@vikingline.com, tel. +358 18 270 00

Christa Grönlund, informationschef

christa.gronlund@vikingline.com, tel. +358 9 123 51

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